Regulation between immune activation and tolerance is crucial in the pathogenesis of cancer.
Recent development of intravital 2-photon microscopy allows direct observation of how immune cells traffick and interact with various cells in the tumor microenvironment in real time with single-cell resolution.
Our laboratory is interested in applying this and other classical immunological techniques to study various aspects of anti-tumor immune responses, immune – host – pathogen interaction, T cell-mediated memory immunity, and chemokine - receptor biology.
The long-term goal of our laboratory is to translate insights gained from basic investigations of in vivo immunity into rationally designed tumor vaccine and immunotherapeutic clinical trials, with a particular emphasis in the areas of pediatric sarcomas and other solid tumors.